Saturday, June 16, 2012

Mythbusting 101: bulking up with bull shark testosterone

This week, the startling image of a 1,000 pound bull shark has been circulating the internets. But what really caught my eye was the quote from the lead researcher, Neil Hammerschlag. He told news outlets that bull sharks ?have the most testosterone of any animal on the planet, so that should tell you a little something.? Tsk tsk, Neil. No matter what those websites tell you, it?s simply not true.

This isn?t the first time I have heard this whole bull sharks and testosterone bit. Indeed, all over the internet, you see claims that bull sharks are so aggressive because of their insane testosterone levels. But it was the character Bruce Kibbutz in Grand Theft Auto IV that really got people talking about bull shark testosterone. During the game, the roid-raging fitness freak explains how he juices on testosterone taken from Chilean bull sharks. Suddenly, extreme body builders and skeptics wanted to know if you could really bulk up on bull shark blood.

The rumor, as I?d heard it in college, is that the fierce attitudes of these large and aggressive sharks is due to unfathomably high circulating levels of testosterone. Specifically, these menacing monsters supposedly have higher serum testosterone levels than any species on the planet, land or sea, and that even a female bull shark has higher levels than a testosterone-raged male elephant in musth. I know I?m as much to blame as anyone, as I?ve repeated that line myself. But when I was asked about it, I realized that I didn?t know if it?s true. How do the circulating testosterone levels compare between bull sharks and other species? Could you procure enough testosterone by catching and eating bull sharks to beef up your body?

Let?s start with that elephant. In the red corner, standing up to 11.5 feet tall and weighing in at up to 20,000 lbs, we have the African Bush Elephant (Loxodonta africana). What?s the testosterone level in this whomping beast? During much of the year, not much. Male elephants, on average, have less than 2 ng/ml ciculating in their plasma. But wait! Big boy wants to get his groove on, and he is getting ready for a season of fighting and fornicating. So what?s the male elephant in musth?s testosterone level? As high as 64.4 ng/ml! About a 60 fold increase in average circulating testosterone1. Ai! That?s a lot of anger-pumping hormone.

How about his opponent, the every day female bull shark (Carcharhinus leucas)? In the blue corner, weighing in at around 505 lbs and stretching almost 12 feet long, is our large and in charge girl. She?s bigger than her man, no doubt, but she still has to keep her femininity about her. After all, as a girl, if her testosterone levels are too high, she might have reproductive issues. Surely her circulating levels are lower than the male elephant?s?

According to the only, extremely obscure published reference with testosterone levels in a female bull shark, actually, yes, they are2. Her circulating testosterone level is right around 0.1 ng/ml, a whole lot lower than that angry elephant. Sorry to burst bubbles, but she ain?t gonna give anyone roid rage. Her man, though? My oh my. One of the two male adult bull sharks in that study had a circulating testosterone level of 358 ng/ml. Yeah, that?s one roided out shark. Problem is, the other male bull shark in that study only had 2.7 ng/ml of testosterone in his serum ? which is probably less than you male readers out there have pumping in your blood right now. So not all male bull sharks are running around roided out of their minds. To be fair, these were just single sharks, caught once and tested once. Without a more complete study of the average hormone levels in bull sharks, by size, season, etc, we can?t really say that bull sharks have abnormally high or low testosterone levels.

Of course, there is a more complete study. Not a super detailed one, but a study none the less. Rasmussen & Murru3 studied androgen levels in a number of captive sharks over time. They found testosterone levels of 10 ng/ml to 20 ng/ml in two captive bull sharks when they measured every June for three years, just after the sharks? normal breeding season. Not too impressive, boys ? not too impressive, but of course, that is in captivity, and it?s unknown how captivity may affect their hormone levels.

In wild bull sharks caught right before the breeding season, the serum levels were much higher: 185 ng/ml on average ? which was 4 to 10 times higher than the levels they found in two other shark species, and is pretty impressive compared to the elephant. But, it turns out, it?s not that hard to find high testosterone levels in fish. Other sharks have high levels, too ? like the bonnethead, Sphyrna tiburo, whose highest levels have been recorded at 303 ng/ml4. And in that species, even the girls have higher levels than our elephant ? a whopping 74 ng/ml at max5. Believe me, I?d rather go hunting bonnethead than bull sharks any day. Other fish, too, have been found to have high testosterone. Male rainbow trout have levels around the same as those of the bonnetheads6, and heck, they sound a whole lot tastier to me than the other options. Just sayin?. Sorry folks, but according to the best, albeit limited scientific information we have, the idea that bull sharks are super juiced-up compared to other animals just isn?t true.

Yet in the news and even on the Discovery Channel?s infamous Shark Week, the highest-testosterone-in-the-world bull shark is the norm. How did the data end up so skewed towards this single result? As I see it, it is the scientific community that is to blame for the impression that bull sharks are testosterone-pumped. Every other paper I read about shark hormones since the two with bull sharks cites them, specifically mentioning 358 ng/ml and that bull sharks have much higher levels than other sharks.

Now that I read the papers, I see it?s not the media?s fault. It?s the original authors that claim that bull sharks have higher testosterone than other sharks, even without presenting evidence to back it up. It started with how Rasmussen & Gruber were quick to point out how high that 358 ng/ml value is, saying it?s ?among the highest recorded in vertebrate serum,? but didn?t talk at all about why the other mature male bull shark (by their own identification) was more than one hundred fold lower. But it?s really Rasmussen & Murru (hmm? that first name sounds familiar), in their discussion, who seem to overinflate their own data. They state that ?a species differences in absolute concentrations appears to exist because concentrations of testosterone in both wild and captive bull sharks were about two times higher than those in mature sandbar and lemon sharks? (emphasis mine). Yet their included figure showing the yearly serum concentrations for the two captive bull sharks studied clearly shows the levels between 5 ng/ml and 20 ng/ml, while the levels for the two captive sandbar sharks sampled at the same and different times of year range from 0 ng/ml to over 40 ng/ml! Two to four times higher in bull sharks? Where? When?!

But enough griping about inaccurate inflation of results. Let?s say, for a hypothetical moment, that there is a time of year, size, or whatever where you could go out with a shark hook and some dead fish and guarantee getting a big boy bull shark with upwards of 300 ng/ml in his system. It?s time to address the other part of the myth: Should serious users think about going fishing?

You?ll have one big fish to fry if you?re trying to get a nice dose of testosterone by ingesting sea creatures. First off, I hope you?re feeling vampiric. You want the blood, not the tissues. We don?t know anything about how much testosterone is in bull shark tissues, and besides, that super high amount was in the blood? so, yeah. Cheers. Second off, unless you?re planning on shooting up shark blood, you?re not getting the dose you think. Orally ingested testosterone is rapidly absorbed by the gut, but it?s also converted to inactive metabolites, leaving you with only 1/6th the dose you took remaining in active form. That?s why pills and injections aren?t actually of straight testosterone, they?re of slightly modified chemicals that the body doesn?t metabolize as easily. It also means that to get the same dose from shark as you would from a prescription (or black market) pill, you have to drink six times what you think you have to.

So let?s say you want to replace that 40 mg pill you bought with bull shark blood. Even if you catch that one shark that had 350 ng/ml in his serum, that means you?ll have to drink down three cups of shark plasma to equal one pill. A shark tends to be about 12.3% blood by weight according to previous studies7 ? that?s 6.8% blood cells and 5.5% serum, which has a specific gravity (weight per volume) of around 1.03. So say you caught an average bull shark, weighing only 350 lbs instead of the max of 500. He?ll have around 44 cups of blood in him, which is only 44% plasma, so you?ll need to drink 6.8 cups of blood per pill. So at 2-5 pills a day, that shark will only last you one to three days. Hey ? I guess it?s legal. Though somehow, I don?t think athletes are going to get away with the old ?I was just drinking shark blood? excuse just because of that.

Of course, all of that assumes that the majority of bull sharks are swimming around with high testosterone levels, which as the data reveals, simply isn?t likely. What?s worse, though, is that by perpetuating the idea of roided-out sharks, we?re giving credence to the idea that bull sharks are mindless killing machines with a taste for blood. While bull sharks are certainly dangerous animals, they are far from the angry maneaters they?re portrayed to be. Given that you?re still more likely to die from being struck by lightning that by a shark attack, and that there are probably hundreds of thousands of bull sharks in the Atlantic Ocean alone? I?d say the bull sharks are being pretty restrained.

?

Citations: 1. JAINUDEEN, M., KATONGOLE, C., & SHORT, R. (1972). PLASMA TESTOSTERONE LEVELS IN RELATION TO MUSTH AND SEXUAL ACTIVITY IN THE MALE ASIATIC ELEPHANT, ELEPHAS MAXIMUS Reproduction, 29 (1), 99-103 DOI: 10.1530/jrf.0.0290099
2. Harold L. Pratt, Jr., Samuel H. Gruber, & Toru Taniuchi (editors) (1990). Elasmobranchs as Living Resources: Advances in the Biology, Ecology, Systematics, and the Status of the Fisheries NOAA Technical Report NMFS 90, 143-155
3. Rasmussen, L., & Murru, F. (1992). Long-term studies of Serum Concentrations of reproductively related Steriod Hormones in individual captive Carcharhinids Marine and Freshwater Research, 43 (1) DOI: 10.1071/MF9920273
4. Manire, C. (1997). Serum Concentrations of Steroid Hormones in the Mature Male Bonnethead Shark,Sphyrna tiburo General and Comparative Endocrinology, 107 (3), 414-420 DOI: 10.1006/gcen.1997.6937
5. Manire, C. (1995). Serum Steroid Hormones and the Reproductive Cycle of the Female Bonnethead Shark, Sphyrna tiburo General and Comparative Endocrinology, 97 (3), 366-376 DOI: 10.1006/gcen.1995.1036
6. Scott, A. P., & Baynes, S. M. (1982). Plasma levels of sex steroids in relation to ovulation and spermiation in rainbow trout (Salmo gairdneri) Proc. Int. Symp. Reprod. Physiol. Fish, 103-106
7. Thorson, T. (1962). Partitioning of Body Fluids in the Lake Nicaragua Shark and Three Marine Sharks Science, 138 (3541), 688-690 DOI: 10.1126/science.138.3541.688

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TheAdvice.com Publishes New Articles on ... - Home Equity Loan

Personal Finance Expert Walter Edelstein has published new content on TheAdvice.com Personal Finance Site Network that provides retirement advice on spousal Social Security benefits and banking advice on how consumers can avoid making mistakes with their checking accounts.

Bayside, N.Y. (PRWEB) June 14, 2012

Personal Finance expert Walter Edelstein, CFP? is providing updated financial information and advice on several important topics including retirement advice on choices consumers can make about spousal Social Security benefits and banking advice on how consumers can make better use of their checking accounts. TheAdvice.com Personal Financial Site Network continues to provide consumers with free information and easy to implement practical ideas to help them achieve their personal financial goals. following is a summary of some of the new articles published on TheAdvice.com Personal Finance Site Network.

How do Spousal Social Security Benefits Work?

Even as the discussion surrounding Social Security becomes increasingly rancorous, many retirees still rely on the program for a significant portion of their retirement income. In fact, because many people find themselves in a much worse position than they anticipated with respect to their retirement nest egg, Social Security payments sometimes represent a necessary element of their retirement planning process.

Most people already understand that a person becomes eligible to receive Social Security benefits by working and paying Social Security taxes. but according to mr. Edelstein, ?What?s not as widely known is that spouses of workers may also be eligible to receive Social Security, even if they themselves never pay Social Security taxes.? This articles describes the spousal Social Security benefit and provides advice about choices consumers can make to get the most of that benefit.

Checking Account Mistakes that Should be Avoided

Checking accounts are essential to managing day-to-day personal finances. Consumers deposit most or all of their paychecks into checking accounts, and use that account to pay bills, manage household finances and conduct practically every other financial transactions that is done.

Given how important checking accounts are, it?s a bit surprising that consumers don?t always do the right things when it comes to how they manage them. According to Edelstein, ?People make far too many mistakes when it comes to their checking accounts, and while the consequences of a single mistake might not be too serious, the total effect of multiple mistakes over time can be quite significant.? This article highlights some of the mistakes that can be avoided if consumers follow some simple steps.

About TheAdvice.com Personal Finance Site Network

TheAdvice.com Personal Finance Site Network was launched in 2009, and since then has provided consumers with hundreds of free articles and financial tips across a broad array of personal finance topics. Several of the sites in TheAdvice.com Personal Finance Site Network include:

Credit Card Advice ? where consumer can learn how to establish credit, protect credit, choose the right credit card, and unlock the secrets of a credit report.

Insurance Advice ? where consumers can find answers to many insurance questions including how to secure the right coverage for all home, health, life and automobile insurance needs.

Mr. Edelstein has financial experience that spans over thirty years. It includes being a Certified Financial Planner?, having a Master?s Degree from Columbia University, and having served as Chief Marketing Officer for a major online bank where he honed his online marketing skills to help consumers achieve their financial goals.

TheAdvice.com proudly reaches out with this network of personal finance websites to help individuals and families discover the path to financial knowledge.

For the original version on PRWeb visit: prweb.com/releases/prwebretirementadvice/banking/prweb9601784.htm

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Dueling Speeches (talking-points-memo)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

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Yelp serves restaurant reviews to Microsoft's Bing

SAN FRANCISCO (AP) -- Yelp is feeding its online reviews of restaurants and other local merchants to Microsoft's Bing search engine in a move to compete against Zagat ratings on Google.

Beginning Thursday, people using Bing to search for information about neighborhood businesses will be able to see excerpts from Yelp reviews.

The deal between Microsoft Corp. and Yelp Inc. comes two weeks after Google unveiled a new feature that serves up restaurant ratings from Zagat. Google Inc. bought Zagat's popular rating service for $151 million last year. To attract more people, Google scrapped the online fees that Zagat charged to read its ratings.

Google's decision to highlight Zagat in its influential search results threatens to divert traffic from Yelp. Joining forces with Bing makes sense for Yelp because both online services are locked in battle against Google to attract more advertising from local merchants.

Microsoft and Yelp also have complained that Google promotes its own services in its search results to stifle competition, allegations that are under investigation by government regulators in the U.S. and Europe.

Google processes about two out of every three search requests in the U.S., leaving Bing a distant second in the Internet's most lucrative search market. Microsoft has been unable to make much headway against Google, despite pouring billions of dollars into improving its search technology.

The Bing alliance marks the second time this week that Yelp has gotten a boost from a Google rival. On Monday, Apple Inc. previewed a new mapping service for its iPhone and iPad that will feature business reviews from Yelp. Apple's maps, due out this fall, will replace Google's navigation service as the built-in option in the next version of the operating system that powers the iPhone and iPad.

Yelp's latest deal didn't buoy its stock. The company's shares fell 17 cents to $19.61 in Thursday afternoon trading. Yelp, which is based in San Francisco, went public in March at $15 per share.

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Cost of kid-raising hits $234,900 in U.S

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Israel contemplates pre-emptive strike on Syria

Ehud Barak, Israel?s defense minister, has ordered the country?s military to plan for a series of pre-emptive strikes on Scud missile sites and suspected weapons of mass destruction in Syria. The current rebellion against the Bashar Al-Assad regime is believed to have reached a dangerous phase, while concerns over the dangerous weapon stockpiles and delivery systems has been a constant concern. According to local media, Israel Defense Forces have increased its surveillance of military bases across Syria, a traditional enemy, such as insurgents have overrun some military and government installations.

U.S. and Israeli intelligence suggest that some of the rebel groups, that are affiliated with the Al-Qaeda terrorist network, have entered Syria via Iraq. As the possibility looms that fanatical Muslim terrorist may soon possess tactical missiles and weapons of mass destruction, Defense Minister Barak confirmed that Israel is closely watching the events and may be forced to take pre-emptive action should the situation deteriorate further.

Sources in Israel suggest that the IDF is planning for two possible scenarios: Should defecting or retreating Syrian government forces transfer advanced Scud missiles and/or chemical weapons to the Hizbullah terrorist organization, which has been cooperating with Assad?s forces, Israel would attack targets to prevent the transfers. In a second scenario, should al Qaeda terrorist secure either a chemical weapons facility or Scud missile base, then Israel would attack.

?There are media reports in Israel that the United Nations and the U.S. have expressed concerns to leaders of the Syrian insurgents about Al Qaeda?s operation in Syria. Reportedly, the White House and CIA have allegedly told Defense Minister Barak that it would be almost impossible for elite ground and air forces to find and destroy all of Assad?s widely dispersed WMD facilities.

Israeli media also reported that Prime Minister Benjamin Netanyahu, Defense Minister Barak and IDF Chief of Staff Benny Gantz, are seeking to determine the means to attack Syria?s dangerous missiles and WMD stockpile with risking a widening war with Syria and Hisbullah. The Israeli government and military establishment have expressed concerns that President Assad (and Iran) may wish to embark on war with Israel and thus divert insurgents? attention away from his regime.? Under this scenario, the Sunni anti-Assad rebels would attack Iran?s Hizbullah-allied Shiite forces in retaliation for their direct involvement in the massacre of innocent Syrian civilians.

Israel is not taking any chances. The country?s Homefront Command is preparing for the mass evacuation of Israelis from northern and central Israel. In case of a significant missile attack against Haifa, Netanya and Tel Aviv, citizens would be evacuated to hotels, public buildings and tent cities at Eilat and the Jordan Valley.
?

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Achtung! Germany gets Google Play Books

Google Play Books

Good news for our friends and readers (both, I guess; they're not mutually exclusive) in Germany. You've now got access to Google Play Books. That means easy purchasing through Google Play, and easy reading through the Play Books application.

Now ... Which George R.R. Martin book to begin with?

via @chowdarygm



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